Detoxification Enhancer (120 Capsules)

$38.00

Detoxification Enhancer™ is a convenient, cost-effective, unique, powerful formula delivering potent levels of ingredients formulated to promote balanced activity between Phase 1 and Phase 2 detoxification processes. Detoxification Enhancer™ should be used as part of an overall detoxification protocol that supplies adequate high quality protein, carbohydrates, fats and fiber.

All Arthritis Center Of Riverside® Formulas Meet or Exceed cGMP Quality Standards.

 

Directions:

Take two capsules, twice daily, or as directed by your healthcare professional.  Must be taken 4 hours away from certain antibiotics.

Cautions:

If pregnant or nursing or taking medications, consult your practitioner. Green tea catechins may decrease platel aggregation.8
The information contained in this paper has not been evaluated by the FDA.  The associated product is not intended to diagnose, treat, cure, 
or prevent any disease.
SKU: 1020 Category:

Description

Discussion:
The term “Dual Phase Optimizers” refers to those substances with the ability to simultaneously influence and “optimize” the activity of certain Phase 1 and Phase 2 enzyme systems. Optimizers generally upregulate or induce Phase 2 enzymes; however, optimizing Phase 1 enzymes may mean down-regulating them when they are too high without totally inhibiting them. Dual Phase Optimizers may further balance the phases of detoxification by acting as antioxidants and binding dangerous free radicals formed between the two phases.
     Examples of Dual Phase Optimizers in Detoxification Enhancer™ are ellagic acid from pomegranate, catechins from green tea extract and glucosinolates from watercress powder. Ellagic acid can bind directly to DNA to protect it and bind directly to some toxic substances to promote their excretion. In addition, ellagic acid induces Phase 2 enzymes at the gene level and makes sure these are not over-induced by its modulation of CYP1A activities.1,2 The catechins in green tea, besides being strong antioxidants, also can bind directly to toxic substances. They have the ability to modulate Phase 1 enzymes, moderately up-regulating them when carcinogens are not present and limiting the enzyme production when toxic substances are encountered.3Glucosinolates are precursors to isothiocya-nates. In particular, watercress is metabolized by gut flora into phenylethyl isothiocyanate (PEITC) which like the other ingredients above, can selectively inhibit Phase 1 enzymes and induce the activities of Phase 2 enzymes.4
     As the liver is one of the main organs for detoxification, silymarin (milk thistle seed extract) and artichoke leaf extract and alpha lipoic acid have been added to the formula because they are hepatoprotectant. They also increase glutathione and provide potent antioxidant protection.5,6,7
     The remaining ingredients in this formula are present to support the various Phase 2 detoxification pathways. Vitamins B6, B12 and folate, along with MSM support methylation. Calcium D-Glucarate has been added to support glucuronidation. The sulfate donors, sodium sulfate and NAC are especially important in cases of heavy metal burden because they support glutathione production and the sulfation pathway.   

References:

1. Barch DH, Rundhaugen LM, Stoner GD, Pillay NS, Rosche WA Structure-function relationships of the dietary anticarcinc ellagic acid. Carcinogenesis. 1996 Feb;17(2):265-9. [PMID: 8625448]
2. Bala I, Bhardwaj V, Hariharan S, Kharade SV, Roy N, Ravi Kumar MN. Sustained release nanoparticulate formula containing antioxidantellagic acid as potential prophylaxis system for oral administration. J Drug Target. 2006 Jan;14(l):27-: [PMID: 16603449]
3. Yang SP, Wilson K, Kawa A, Raner GM.Effects of green tea extracts on gene expression in HepG2 and Cal-27 cells. Food CI Toxicol. 2006 Jul;44(7):1075-81. Epub 2006 Feb [PMID: 16487642]
4. von Weymarn LB, Chun JA, HoUenberg PE Effects of benzyl and phenethyl isothiocyanate on P450s 2A6 and 2A13: pote: for chemoprevention in smokers. Carcinogenesis. 2006 Apr;27(4):782-90. Epub 2005 Dec 19 [PMID: 16364922]
5. Perez-Garcia F, AdzetT, Canigueral S. Activity of artichoke leaf extract on reactive oxygen species in human leukocytes. 1 Radic Res. 2000 Nov;33(5):661-5. [PMID: 11200096]
6. Nencini C, Giorgi G, Micheli L Protective effect of silymarin on oxidative stress in rat brain. Phytomedicine. 2006 Api [PMID: 16638633]
7. Abdel-Zaher AO, et al. The potential protective role of alpha-lipoic acid against acetaminophen-induced hepatic and r damage. Toxicology. 2008 Jan 20;243 (3) :261-70. Epub 2007 Oct 23 [PMID: 18068886]
8. Neuhaus T, Voit S, et al. Platelet aggregation induced by the C-terminal peptide of thrombospondin-1 (4N1-1) is inhibitei epigallocatechin gallate but not by prostaglandin El. Platelets. 2004 Nov;15(7) :455-7 [PMID: 15745318].
The information contained in this paper has not been evaluated by the FDA. The associated product is not intended to diagnose, treat, cure, 
or prevent any disease.