Joint Support (120 Capsules)

$39.50

Joint Support features eicosatetraenoic acids derived from New Zealand green-lipped mussels. The green- lipped mussel (Perna canaliculus) contains these naturally occurring omega-3 fatty acids along with glycosaminoglycans (GAGs), the principal component of cartilage and synovial fluid found in the joints. Hyaluronic acid, glucosamine, chondroitin sulfate, MSM (methylsulfonylmethane), and manganese are added to support antioxidant activity, collagen biosynthesis, and joint tissue health.*

All Arthritis Center Of Riverside® Formulas Meet or Exceed cGMP quality Standards.

Directions:

Take two capsules twice daily, or as directed by your healthcare practitioner.

Cautions:

Consult your healthcare practitioner before use. Keep out of reach of children. Avoid if allergic to any ingredient.

SKU: 1029 Category:

Description

Discussion:

Joint Support is a multi-faceted approach to supporting joint health. The ingredients in this formula address many pathways that play important roles in the health of joint tissues, including eicosanoid metabolism, protection from oxidative stress, and glycosaminoglycan (GAG) and collagen synthesis.*

Green-Lipped Mussel (GLM) (Perna canaliculus) Arthritis Center of Riverside’s GLMs are sourced from clear, unpolluted waters off New Zealand and are tested and guaranteed to be pure. They contain GAGs, the principal components of cartilage and synovial fluid, as well as eicosatetraenoic acid, which promotes a healthy response to inflammation and supports a healthy joint environment.  GLMs have been shown to inhibit inflammatory COX-1, COX-2, and lipoxygenase enzymes.  Results of a systematic review of human randomized or placebo-controlled trials of GLM concluded that all trials reported benefit in helping to maintain healthy joint tissue and function.*

Glucosamine Hydrochloride, Chondroitin Sulfate, and Methylsulfonylmethane (MSM)Glucosamine is an amino sugar† that is believed to stimulate chondrocytes (cartilage cells), support GAG synthesis, incorporate sulfur into cartilage, and induce hyaluronic acid production.  As a primary proteoglycan, chondroitin is a major component of articular cartilage. It is believed to help cartilage tissue retain water, which is needed for resistance and elasticity. Glucosamine and chondroitin may also have protective effects on cartilage.  Furthermore, meta-analyses of randomized placebo-controlled trials have demonstrated the efficacy of chondroitin sulfate in supporting healthy cartilage structure.  Animal and human studies suggest that glucosamine hydrochloride administration supports healthy levels of GAGs and proteoglycans in cartilage as well as type II collagen balance.*

MSM, a naturally occurring, sulfur-containing, water-soluble compound also known as DMSO2, has been shown to remain in the blood up to five times as long as the related compound, DMSO. MSM may help protect cartilage through its effect on the inflammatory response that has been triggered by free radicals, and its ability to provide sulfur.  Sulfur strengthens tissues and cartilage by forming cross-linkages through disulfide bonds in GAGs. In a study performed on 118 subjects, glucosamine and MSM showed better results in supporting joint health and function when combined than when administered individually.  The MSM in Joint Support is provided as OptiMSM®, which is known for its purity, quality, and consistency.*

Hyaluronic Acid This naturally occurring GAG found in synovial fluid helps create a viscous environment to cushion joints and help maintain normal function. It has both cytokine-modulating and antioxidant properties. Experimental research also suggests that hyaluronic acid influences cell-signaling in a manner that protects cultured human chondrocytes and collagen biosynthesis.  A randomized double- blind controlled trial performed on 40 subjects supplementing with 80 mg/day of a 60% hyaluronic acid compound for eight weeks suggests that it supports physical and social functioning related to joint health.*

Vitamin C and Manganese Vitamin C is essential for every step in the synthesis of collagen and for maintaining collagen integrity, yet it is destroyed during collagen biosynthesis. An animal study also suggests that serum ascorbate levels have an influence on fluid accumulation in the joint.  Manganese, provided in this formula as an Albion® TRAACS® chelate, is important in the growth and development of normal bone and in the synthesis of cartilage. Studies have demonstrated a supportive, cytokine-modulating effect on joints when glucosamine, chondroitin, and manganese are combined.*

†Glucosamine does not appear to have an effect on sugar levels when measured by glucose tolerance tests or hemoglobin A1C readings.

References:

1. Brien S, Prescott P, Coghlan B, et al. Systematic review of the nutritional supplement Perna Canaliculus (green-lipped mussel) in the treatment of osteoarthritis. QJM. 2008 Mar;101(3):167-79. [PMID: 18222988]

2. McPhee S, Hodges LD, Wright PF, et al. Anti-cyclooxygenase effects of lipid extracts from the New Zealand green-lipped mussel, Perna canaliculus. Comp Biochem Physiol B Biochem Mol Biol. 2007 Mar;146(3):346-56. [PMID: 17197217]

3. Treschow AP, Hodges LD, Wright PF, et al. Novel anti-inflammatory omega-3 PUFAs from the New Zealand green-lipped mussel, Perna canaliculus. Comp Biochem Physiol B Biochem Mol Biol. 2007 Aug;147(4):645-56. [PMID: 17543561]

4. Dahmer S, Schiller RM. Glucosamine. Am Fam Physician. 2008;78(4):471-76. [PMID: 18756654]

5. Igarashi M, Kaga I, Takamori Y, et al. Effects of glucosamine derivatives and uronic acids on the production of glycosaminoglycans by human synovial cells and chondrocytes. Int J Mol Med. 2011 Jun;27(6):821-7. doi: 10.3892/ijmm.2011.662. [PMID: 21455564]

6. Wildi LM, Raynauld JP, Martel-Pelletier J, et al. Chondroitin sulphate reduces both cartilage volume loss and bone marrow lesions in knee osteoarthritis patients starting as early as 6 months after initiation of therapy: a randomised, double-blind, placebo-controlled pilot study using MRI. Ann Rheum Dis. 2011 Jun;70(6):982- 89. [PMID: 21367761]

7. Hochberg MC. Structure-modifying effects of chondroitin sulfate in knee osteoarthritis: an updated meta-analysis of randomized placebo-controlled trials of 2-year duration. Osteoarthritis Cartilage. 2010 Jun;18 Suppl 1:S28-31. [PMID: 20399895]

8. Ivanovska N, Dimitrova P. Bone resorption and remodeling in murine collagenase-induced osteoarthritis after administration of glucosamine. Arthritis Res Ther. 2011 Mar 16;13(2):R44. [PMID: 21410959]

9. Kanzaki N, Saito K, Maeda A, et al. Effect of a dietary supplement containing glucosamine hydrochloride, chondroitin sulfate and quercetin glycosides on symptomatic knee osteoarthritis: a randomized, double-blind, placebo-controlled study. J Sci Food Agric. 2012 Mar 15;92(4):862-69. [PMID: 21969261]

10. Kim LS, Axelrod LJ, Howard P, et al. Efficacy of methylsulfonylmethane (MSM) in osteoarthritis pain of the knee: a pilot clinical trial. Osteoarthritis Cartilage. 2006 Mar;14(3):286-94. [PMID: 16309928]

11. Usha PR, Naidu MU. Randomised, double-blind, parallel, placebo-controlled study of oral glucosamine, methylsulfonylmethane and their combination in osteoarthritis. Clin Drug Investig. 2004;24(6):353-63. [PMID: 17516722]

12. Campo GM, Avenoso A, Campo S, et al. Aromatic trap analysis of free radicals production in experimental collagen-induced arthritis in the rat: protective effect of glycosaminoglycans treatment. Free Radic Res. 2003;37(3):257-68. [PMID: 12688421]

13. Karna E, Miltyk W, Surazyñski A, et al. Protective effect of hyaluronic acid on interleukin-1-induced deregulation of beta(1)-integrin and insulin-like growth factor-I receptor signaling and collagen biosynthesis in cultured human chondrocytes. Mol Cell Biochem. 2008;308(1-2):57-64. [PMID: 17899316]

14. Kalman DS, Heimer M, Valdeon A, et al. Effect of a natural extract of chicken combs with a high content of hyaluronic acid (Hyal-Joint) on pain relief and quality of life in subjects with knee osteoarthritis: a pilot randomized double-blind placebo-controlled trial. Nutr J. 2008 Jan 21;7:3. [PMID: 18208600]

15. Simões SI, Eleutério CV, Cruz ME, et al. Martins MB. Biochemical changes in arthritic rats: dehydroascorbic and ascorbic acid levels. Eur J Pharm Sci. 2003;18(2):185-89. [PMID: 12594012]

16. Das A Jr, Hammad TA. Efficacy of a combination of FCHG49 glucosamine hydrochloride, TRH122 low molecular weight sodium chondroitin sulfate and manganese ascorbate in the management of knee osteoarthritis. Osteoarthritis Cartilage. 2000 Sep;8(5):343-50. [PMID: 10966840]

17. Muniyappa R, Karne RJ, Hall G, et al. Oral glucosamine for 6 weeks at standard doses does not cause or worsen insulin resistance or endothelial dysfunction in lean or obese subjects. Diabetes. 2006 Nov;55(11):3142-50. [PMID: 17065354]

These statements have not been evaluated by the Food and Drug Administration. This product is not not intended to diagnose, treat, cure, 
or prevent any disease.