Memory Support™ (60 Capsules)

$41.38

Clinical Applications
• Helps Support Normal, Healthy Cognitive Function*
• May Support the Health of Brain Tissue*

Memory Support is a unique combination of nutrients and botanicals that supports cognitive function and a healthy memory. It features select B vitamins, including Quatrefolic®, a patented form of 5-MTHF; the herbs Gingko biloba and Bacopa monnieri; nutrients that provide antioxidant activity; and brain-specific nutrients such as vinpocetine, acetyl-L-carnitine, and sunflower-derived phosphatidylserine. This comprehensive formula addresses the multiple pathways involved in neurological health by supporting oxidant and cytokine balance, methylation, mitochondrial function, and endocrine balance.*

Directions
Take one capsule twice daily, or as directed by your healthcare practitioner.

Does Not Contain
Wheat, gluten, corn, yeast, soy, animal or dairy products, fish, shellfish, peanuts, tree nuts, egg, ingredients derived from genetically modified organisms (GMOs), artificial colors, artificial sweeteners, or preservatives.

Cautions
Consult your healthcare practitioner before use, especially if you have low blood pressure, are taking blood-thinning agents, or are within two weeks before or after undergoing surgery. Do not take if you are pregnant or lactating. Do not use if tamper seal is damaged.

SKU: 1030 Category:

Description

Discussion
Vitamins B6 (as pyridoxal 5’-phosphate), B12 (as methylcobalamin), and folate (as 5-MTHF) are essential homocysteine
remethylation cofactors; as such, they support the maintenance of healthy homocysteine levels. Normal blood levels of
homocysteine are associated with healthy cognition in the elderly and healthy cerebrovascular function.[1] The brain may be
protected by improving methylation by providing the nutritional cofactors needed for proper functioning of the methionine
cycle.*[2]

5-MTHF (5-methyltetrahydrofolate) may better support folate nutrition in those with digestive issues and those with genetic
variations in folic acid metabolism. The form of 5-MTHF in Memory Support is Quatrefolic, which is proven to have greater
stability, solubility, and bioavailability over calcium salt forms of 5-MTHF.*

N-Acetyl-Cysteine is capable of crossing the blood-brain barrier and is known to combat oxidative stress, and reduced
oxidative stress may support healthier nerve tissue.[3] L-carnitine is a vital cofactor for mitochondrial oxidation of fatty acids
providing the brain with an energy substrate. Acetyl-L-carnitine, an ester of L-carnitine, possesses properties that may
be effective in supporting healthy cognition with age.[4,5] The phospholipid phosphatidylserine (PS) plays an important
functional role in membrane-related processes in the brain and regulates the release of acetylcholine, dopamine, and
noradrenaline. PS appears to support neuronal health and healthy brain function, possibly through its effect on cytokine
production and their influence on microglia.*[6]

Ginkgo biloba leaf extract contains two main bioactive constituents—ginkgoflavonglycosides (24%) and terpene lactones
(6%)—and is used in the formula because of its reported stress-alleviating and memory-supportive effects as well as its
ability to support the health and integrity of neurons. The mechanisms of action may be mediated through its antioxidant,
antihypoxic, and microcirculatory actions.[7] The Ayurvedic herb Bacopa monniera has reported cognition-facilitating,
cytokine-modulating, and anti-stress effects. These effects are thought to be mediated through its remarkable free-radical–
scavenging capacity and its protective effect on DNA cleavage.*[8]

Vinpocetine is derived from vincamine, an alkaloid extracted from the periwinkle plant (Vinca minor). It has been used
extensively in Eastern Europe, and more recently in the United States, to support cerebrovascular health and healthy
mental function. Vinpocetine’s roles in supporting brain function are multi-modal and include its influence on cerebral
circulation, its antioxidant activity in the brain, and its role in affecting ion channels and cytokine production.[9-11] Together,
these varied actions support overall brain tissue health and function. The efficacy and safety of vinpocetine have been
tested and validated by in vitro, animal, and human studies. Many human studies demonstrate positive results in neurologic
functioning—primarily related to capillary blood flow and cellular metabolism.*[12-15]

Huperzine A (HupA), like vinpocetine, affects ion channels. Such activity has been found to support healthy learning and
memory. HupA may have a positive effect on levels of acetylcholine through its action on acetylcholinesterase (AChE).
Acetylcholine is one of the chemicals that our nerves use to communicate in the brain, muscles, and other areas. HupA
has been found to support healthy cognition in a broad range of animal models, and phase IV clinical trials in China
demonstrated that HupA was valuable in promoting healthy recall and cognition in elderly subjects.*[16]

References
1. Malouf R, Grimley Evans J. The effect of vitamin B6 on cognition. Cochrane Database Syst Rev. 2003;(4):CD004393. [PMID: 14584010]
2. Miller AL. The methionine-homocysteine cycle and its effects on cognitive diseases. Altern Med Rev. 2003 Feb;8(1):7-19. [PMID: 12611557]
3. Farr SA, Poon HF, Dogrukol-Ak D, et al. The antioxidants alpha-lipoic acid and N-acetylcysteine reverse memory impairment and brain
oxidative stress in aged SAMP8 mice. J Neurochem. 2003 Mar;84(5):1173-83. [PMID: 12603840]
4. Virmani A, Binienda Z. Role of carnitine esters in brain neuropathology. Mol Aspects Med. 2004 Oct-Dec;25(5-6):533-49. [PMID: 15363640]
5. Milgram NW, Araujo JA, Hagen TM, et al. Acetyl-L-carnitine and alpha-lipoic acid supplementation of aged beagle dogs improves learning
in two landmark discrimination tests. FASEB J. 2007 Nov;21(13):3756-62. [PMID: 17622567]
6. Hashioka S, Han YH, Fujii S, et al. Phosphatidylserine and phosphatidylcholine-containing liposomes inhibit amyloid beta and interferongamma-
induced microglial activation. Free Radic Biol Med. 2007 Apr;42(7):945-54. [PMID: 17349923]
7. Mahadevan S, Park Y. Multifaceted therapeutic benefits of Ginkgo biloba L.: chemistry, efficacy, safety, and uses. J Food Sci. 2008
Jan;73(1):R14-19. [PMID: 18211362]
8. Russo A, Izzo AA, Borrelli F, et al. Free radical scavenging capacity and protective effect of Bacopa monniera L. on DNA damage. Phytother
Res. 2003 Sep;17(8):870-75. [PMID: 13680815]
9. Hadjiev D. Asymptomatic ischemic cerebrovascular disorders and neuroprotection with vinpocetine. Ideggyogy Sz. 2003 May;56(5-6):166-
72. [PMID: 12861957]
10. Muravyov AV, Yakusevich VV, Chuchkanov FA, et al. Hemorheological efficiency of drugs, targeting on intracellular phosphodiesterase
activity: in vitro study. Clin Hemorheol Microcirc. 2007;36(4):327-34. [PMID: 17502703]
11. Vinpocetine. Monograph. Altern Med Rev. 2002 Jun;7(3):240-43. [PMID: 12126465]
12. Valikovics A. Investigation of the effect of vinpocetine on cerebral blood flow and cognitive functions [in Hungarian]. Ideggyogy Sz. 2007
Jul;60(7-8):301-10. [PMID: 17713111]
13. Chukanova EI. Efficacy of cavinton in the treatment of patients with chronic blood flow insufficiency. Russian multicenter clinicalepidemiological
program “CALIPSO” [in Russian]. Zh Nevrol Psikhiatr Im S S Korsakova. 2010;110(12):49-52. [PMID: 21311488]
14. Chukanova EI. Cavinton in the complex treatment of patients with chronic cerebrovascular insufficiency [in Russian]. Zh Nevrol Psikhiatr
Im S S Korsakova. 2009;109(9):35-39. [PMID: 19770831]
15. Bagoly E, Fehér G, Szapáry L. The role of vinpocetine in the treatment of cerebrovascular diseases based in human studies [in Hungarian].
Orv Hetil. 2007 Jul;148(29):1353-58. [PMID: 17631470]
16. Wang R, Yan H, Tang XC. Progress in studies of huperzine A, a natural cholinesterase inhibitor from Chinese herbal medicine. Acta
Pharmacol Sin. 2006 Jan;27(1):1-26. [PMID: 16364207]

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.