Methylated B12 Sublingual (60 Tablets)

$30.00

Methylated B12 is a pleasant-tasting, orange-flavored, sublingual tablet of vitamin B12 in its bioidentical form. Studies suggest a greater tissue deposition of cobalamin taken in the methylcobalamin form in comparison to cyanocobalamin. This convenient formula provides 5 mg (5000 mcg) of methylcobalamin per tablet.

All Arthritis Center of Riverside Formulas Meet or Exceed cGMP Quality Standards.

Directions:

Dissolve 1 tablet under your tongue daily or as directed by your healthcare practitioner.

Cautions:

Keep out of reach of children.

SKU: 10007 Category:

Description

Discussion:

The only ways to obtain vitamin B12 are from bacterial synthesis by gastrointestinal flora, from animal-based foods, or from supplementation. Unlike most other water-soluble vitamins, the liver stores vitamin B12 (4 to 6 mg) bound to a protein as methylcobalamin or 5’-deoxyadenosylcobalamin. In time, reserve stores may become depleted following poor dietary intake without supplementation, lack of intrinsic factor, or any other reason for poor intestinal absorption.*

Methylcobalamin and adenosylcobalamin are the two coenzyme forms of vitamin B12. Methylcobalamin participates in transmethylation reactions. As a cofactor in the enzyme methionine synthase it functions in the regeneration of methionine by transferring its methyl group to homocysteine. Methylcobalamin is the most active of all B12 homologs in the body with respect to nucleic acid and protein and lipid metabolism. Specifically, it is involved in the isomerization of methylmalonyl-CoA to succinyl-CoA, a step in the degradation of the amino acids valine, isoleucine, and threonine, as well as fatty acids with an odd number of carbon atoms. Vitamin B12 is essential to the production of normal fatty acids and therefore essential to the structure and function of cell membranes, including those of the nervous system.*

Vitamin B12 plays an important role in maintenance of the myelin sheath that surrounds nerve cells, and also assists in erythroblast maturation, erythroblast division, and heme synthesis. Deficiency of the vitamin does not allow for the efficient use of the N5-methyl form of tetrahydrofolate for the synthesis of nucleotides needed for DNA replication for the synthesis of red blood cells.*

Many vitamin B12 supplements on the market contain cyanocobalamin. The liver is able to convert a small amount of cyanocobalamin to methylcobalamin; however, research suggests that methylcobalamin is the preferred form for supporting neurological function. Research indicates that liver accumulation of cobalamin is significantly greater with oral methylcobalamin administration than with an equivalent dose of cyanocobalamin. Furthermore, tissue retention of cobalamin was greater when using the methyl- form versus the cyano- form as urinary excretion of methylcobalamin was one third less that of cyanocobalamin.*

References:

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2. Yamazaki K, Oda K, Endo C, Kikuchi T, Wakabayashi. Methylcobalamin (methyl-B12) promotes regeneration of motor nerve terminals degenerating in anterior gracile muscle of gracile axonal dystrophy (GAD) mutant mouse. Neurosci Lett. 1994 Mar 28;170(1):195-7. [PMID: 8041506]

3. Watkins D, Rosenblatt DS. Functional methionine synthase deficiency (cblE and cblG): clinical and biochemical heterogeneity. Am J Med Genet. 1989 Nov;34(3):427-34 [PMID: 2688421]

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6. Sakane T, Takada S, Kotani H, Tsunematsu T. Effects of methyl-B12 on the in vitro immune functions of human T lymphocytes. J Clin Immunol. 1982 Apr;2(2):101-9 [PMID: 6461666]

7. Okuda K. Yashima K, Kitazaki T, Takara I. Intestinal absorption and concurrent chemical changes of methylcobalamin. J Lab Clin Med 1973;81:557-567 [PMID: 4696188]

8. Sato, Y, Honda Y, Iwamoto, J, Kanoko, T, Satoh, K,. Effects of folate and mecocobalamin in hip fracture in patients with stroke. JAMA 2005;293(9):1082-1088 [PMID: 15741530]

9. Sato, etal. Amelioration by mecobalamin of subclinical carpal tunnel syndrome involving unaffected limbs in stroke patients. J Neurol Sci, 2005;231(1-2):13-18). [PMID: 15792815]

10. Sun Y, Lai MS, Lu CJ. Effectiveness of vitamin B12 on diabetic neuropathy: systematic review of clinical controlled trials. Acta Neurol Taiwan. 2005 Jun;14(2):48-54 [PMID: 16008162]

11. Takasaki Y, Moriuchi Y, Tsushima H, Ikeda E, Koura S, Taguchi J, Fukushima T, Tomonaga M, Ikeda S. [Effectiveness of oral vitamin B12 therapy for pernicious anemia and vitamin B12 deficiency anemia] Rinsho Ketsueki. 2002 Mar;43(3):165-9. [PMID: 11979747]

12. Poloschek CM, Fowler B, Unsold R, Lorenz B.Disturbed visual system function in methionine synthase deficiency. Graefes Arch Clin Exp Ophthalmol. 2005 May;243(5):497-500. [PMID: 15931548]

13. James SJ, Cutler P, Melnyk S, Jernigan S, Janak L, Gaylor DW, Neubrander JA. Metabolic biomarkers of increased oxidative stress and impaired methylation capacity in children with autism. Am J Clin Nutr. 2004 Dec; 80(6):1611-7 [PMID: 15585776]

14. Yamada N. Treatment of recurrent hypersomnia with methylcobalamin (vitamin B12): a case report. Psychiatry Clin Neurosci. 1995 Dec;49(5-6):305-7 [PMID: 8726119]

15. Ohta T, Ando K, Iwata T, Ozaki N, Kayukawa Y, Terashima M, Okada T, Kasahara Y Treatment of persistent sleep-wake schedule disorders in adolescents with methylcobalamin (vitamin B12). Sleep. 1991 Oct;14(5):414-8. [PMID: 1759094]

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.